Understanding how ion channels affect brain development
Official title: Non-Classical Ion Channel Function in Human Cortical Histogenesis
Funded at Harvard Medical School · NIH-10899915 · Data updated 2026-11-12
This study is looking at how certain genetic changes in ion channels might affect brain development in people with polymicrogyria, a condition that can cause epilepsy and learning challenges, to help find better treatments in the future.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F31NS134253-01A1 |
| Project ID | NIH-10899915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with polymicrogyria or those with unexplained neurological conditions linked to genetic mutations.
✕Less likely to help
Patients without any genetic mutations affecting ion channels or those with unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates the role of ion channels in the development of the human cortex, focusing on a condition called polymicrogyria (PMG), which is characterized by abnormal brain folding and can lead to epilepsy and intellectual disabilities. The researchers have identified genetic mutations in ion channels that may disrupt normal brain development. By analyzing genetic data from families affected by PMG, they aim to uncover how these mutations impact cellular processes critical for brain formation. This work could provide insights into the mechanisms behind PMG and potentially lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with polymicrogyria and related developmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of ion channels in other neurological conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Hylton, Norma Kimberlea — Harvard Medical School
- Study coordinator: Hylton, Norma Kimberlea
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.