Understanding how intestinal signaling affects immune responses and inflammation
Intestinal O-GlcNAc signaling and mucosal host defense
This study is looking at how a certain sugar change on proteins in the intestines affects the immune system, especially during infections and inflammation, to find new ways to help people with allergies and autoimmune diseases feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11018529 on NIH RePORTER |
What this research studies
This research investigates the role of a specific sugar modification on proteins in the intestines and how it influences immune responses, particularly in relation to infections and inflammation. The study aims to understand how this modification can help regulate immune cell differentiation and promote healing in the gut. By exploring the mechanisms behind these processes, the research seeks to identify new therapeutic strategies for treating allergic and autoimmune diseases that arise from an under-stimulated immune system.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from allergic diseases, autoimmune conditions, or chronic intestinal inflammation.
Not a fit: Patients with non-immune related gastrointestinal disorders or those not experiencing allergic or autoimmune symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for allergic and autoimmune diseases by enhancing the body's natural immune responses.
How similar studies have performed: Previous research has shown promising results in understanding immune responses related to intestinal health, suggesting that this approach may yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Ruan, Hai-Bin — University of Minnesota
- Study coordinator: Ruan, Hai-Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.