Understanding how intestinal fungi affect autoimmune diseases
Official title: Gnotobiotic Core
Funded at Sloan-Kettering Inst Can Research · NIH-11061763 · Data updated 2026-11-12
This study is looking at how certain fungi in the gut, especially Candida, might be linked to autoimmune and inflammatory diseases, using special germ-free mice to see how these fungi behave and interact with the immune system, which could help us find new ways to treat these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $295,590 |
| NIH project number | 5P01AI179406-02 |
| Project ID | NIH-11061763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune conditions or inflammatory diseases related to gut health.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by gut microbiome issues may not benefit from this research.
What this research studies
This research investigates the role of intestinal fungi, particularly Candida species, in triggering autoimmune and inflammatory diseases. By using gnotobiotic mouse models, which are germ-free mice, the researchers will explore how these fungi colonize the intestine and the factors that influence their behavior. The study aims to manipulate various bacterial and fungal species in controlled environments to better understand their interactions with the host immune system. This approach could reveal critical insights into the mechanisms behind autoimmunity and inform potential therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases by targeting the interactions between intestinal fungi and the immune system.
How similar studies have gone: Previous research has shown promising results in understanding the role of the microbiome in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Hohl, Tobias M — Sloan-Kettering Inst Can Research
- Study coordinator: Hohl, Tobias M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.