Understanding how intestinal cells sense mechanical changes
Official title: Mechanosensing mechanisms at the intestinal surface
Funded at University of Virginia · NIH-11011727 · Data updated 2026-11-12
This study is looking at how tiny structures on the surface of gut cells help them react to what’s happening around them, which is important for keeping your gut healthy, and it’s designed for anyone interested in understanding more about how our intestines work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | May 2, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $398,598 |
| NIH project number | 1R35GM156345-01 |
| Project ID | NIH-11011727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal disorders or autoimmune conditions affecting the digestive system.
✕Less likely to help
Patients with non-gastrointestinal related conditions or those without any digestive system issues may not benefit from this research.
What this research studies
This research investigates the mechanisms by which intestinal epithelial cells, specifically their microvilli, sense and respond to mechanical and chemical stimuli. By using advanced imaging techniques in live animals, the study aims to uncover the signaling pathways involved in these processes, which are crucial for maintaining gut health. The researchers will explore novel ion channels and signaling molecules associated with microvilli to better understand their role in intestinal function. This approach seeks to bridge the gap between traditional cell culture studies and the complex environment of living tissues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for gastrointestinal disorders by enhancing our understanding of intestinal cell function.
How similar studies have gone: Previous research has shown promise in understanding cellular mechanotransduction, but this specific approach using live animal models is relatively novel.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Ebrahim, Seham — University of Virginia
- Study coordinator: Ebrahim, Seham
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.