Understanding how integrins affect lung barrier function in respiratory distress
Official title: Roles for integrins in control of lung barrier function
Funded at Emory University · NIH-10996100 · Data updated 2026-11-12
This study is looking at how certain proteins in your lungs help keep them working properly, especially for people with acute respiratory distress syndrome (ARDS), which makes it hard to breathe, particularly in those who have a history of alcohol use; the goal is to find new ways to help improve lung function and recovery.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HL168949-02 |
| Project ID | NIH-10996100 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults at risk for ARDS, particularly those with a history of alcohol abuse or other conditions that compromise lung function.
✕Less likely to help
Patients with stable lung function and no history of respiratory distress or alcohol-related issues may not benefit from this research.
What this research studies
This research investigates the role of integrins, which are proteins that help cells stick to each other, in maintaining the barrier function of the lungs. It focuses on acute respiratory distress syndrome (ARDS), a serious condition where the lungs fill with fluid, making it difficult to breathe. The study aims to understand how integrins interact with tight junctions in lung cells and how their dysfunction can lead to ARDS, especially in patients with a history of alcohol abuse. By examining these mechanisms, the research hopes to identify new therapeutic targets to improve lung function and patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung barrier function and reduce the severity of ARDS.
How similar studies have gone: While integrins have been studied in various contexts, this specific investigation into their role in lung barrier function in ARDS is relatively novel and has not been extensively tested.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Ibrahim, Yasmin — Emory University
- Study coordinator: Ibrahim, Yasmin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.