Understanding how insulin works in the liver
Novel effectors of insulin action in the liver
This study is looking at how insulin works in the liver and why it sometimes doesn't help control blood sugar in people with type 2 diabetes, with the hope of finding new ways to improve diabetes treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10532746 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind insulin action in the liver, particularly in relation to type 2 diabetes. It focuses on how insulin can fail to regulate glucose production while still promoting fat storage, leading to high blood sugar and fat levels. The study examines a specific protein complex that may play a crucial role in connecting hormonal signals to the genes that control metabolism. By exploring these interactions, the research aims to uncover new targets for improving diabetes treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes, particularly those struggling to manage their blood sugar levels.
Not a fit: Patients with type 1 diabetes or those without any form of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage blood sugar levels and reduce complications associated with type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding insulin action and its effects on metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Yang, Fajun James — Albert Einstein College of Medicine
- Study coordinator: Yang, Fajun James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.