Understanding how insulin resistance affects heart disease development
Role of Smooth Muscle Cell Insulin Resistance and Systemic Metabolic Dysfunction in Atherosclerosis Development and Late Stage Lesion Pathogenesis
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-10883716
This study is looking at how insulin resistance and metabolic problems, especially in people with type-2 diabetes and metabolic syndrome, can lead to dangerous plaque buildup in blood vessels that might cause heart attacks or strokes, and it hopes to find new ways to help improve heart health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10883716 on ClinicalTrials.gov |
What this research studies
This research investigates the role of insulin resistance and metabolic dysfunction in the development of atherosclerosis, a condition that can lead to heart attacks and strokes. The study focuses on how these metabolic issues, particularly in patients with type-2 diabetes and metabolic syndrome, contribute to the formation of unstable plaques in blood vessels. By examining the cellular mechanisms involved, the research aims to identify potential therapeutic targets that could improve heart health. Patients may be involved in providing samples or data to help understand these processes better.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type-2 diabetes or metabolic syndrome who are at risk for cardiovascular diseases.
Not a fit: Patients without diabetes or metabolic syndrome, or those with other unrelated cardiovascular conditions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart disease in patients with diabetes and metabolic syndrome.
How similar studies have performed: Previous research has shown promising results in understanding the link between metabolic dysfunction and cardiovascular disease, indicating that this approach could lead to significant advancements.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OWENS, GARY K — UNIVERSITY OF VIRGINIA
- Study coordinator: OWENS, GARY K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Atherosclerotic Cardiovascular Disease