Understanding how inositol triphosphate receptors work in cells
Structure and function of inositol triphosphate receptors
['FUNDING_R01'] · VANDERBILT UNIVERSITY · NIH-10872333
This study is looking at special receptors in our cells that help control calcium levels, which is important for many body functions, and it aims to find new ways to treat diseases like cancer and brain disorders by understanding how these receptors work.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-10872333 on ClinicalTrials.gov |
What this research studies
This research investigates inositol 1,4,5-triphosphate receptors (IP3Rs), which play a crucial role in cellular signaling by regulating calcium release in response to various signals like hormones and neurotransmitters. The researchers will use advanced techniques such as cryo-electron microscopy and X-ray crystallography to explore how these receptors function and how they can be targeted by drugs. By understanding the mechanisms of IP3Rs, the research aims to uncover new treatment strategies for diseases like cancer and neurodegenerative disorders that involve calcium signaling dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from cancer, autoimmune diseases, or neurodegenerative disorders.
Not a fit: Patients with conditions unrelated to calcium signaling or those not affected by the diseases targeted in this research may not benefit.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for cancer, autoimmune diseases, and neurodegenerative disorders by targeting IP3Rs.
How similar studies have performed: Previous research has shown promising results in targeting calcium signaling pathways for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARAKAS, ERKAN — VANDERBILT UNIVERSITY
- Study coordinator: KARAKAS, ERKAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases