Understanding how inositol production affects health and disease
Official title: Regulation of inositol biosynthesis and consequences of inositol depletion
Funded at Wayne State University · NIH-11010370 · Data updated 2026-11-12
This study is looking at how our bodies make a substance called inositol, which is important for keeping our cells healthy, and it aims to find out how low levels of inositol might affect conditions like bipolar disorder, cancer, and metabolic diseases, so we can discover new ways to help treat these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $333,995 |
| NIH project number | 5R35GM149271-03 |
| Project ID | NIH-11010370 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with bipolar disorder, certain metabolic disorders, or cancers that may be influenced by inositol levels.
✕Less likely to help
Patients with conditions unrelated to inositol metabolism or signaling may not benefit from this research.
What this research studies
This research investigates the regulation of inositol biosynthesis, which is crucial for cell function and signaling. It aims to understand how inositol depletion impacts various health conditions, including bipolar disorder, cancer, and metabolic diseases. By studying the mechanisms that control inositol levels in human cells, the research seeks to uncover potential therapeutic targets for treating these conditions. The team has already identified a key regulator of inositol synthesis and is exploring its role in cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions linked to inositol depletion, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of inositol in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Greenberg, Miriam L — Wayne State University
- Study coordinator: Greenberg, Miriam L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.