Understanding how injured nerve cells are regulated in autoimmune diseases of the central nervous system
Official title: Mechanisms underlying regulation of injured axons in CNS autoimmunity
Funded at Ohio State University · NIH-11001595 · Data updated 2026-11-12
This study is looking at how certain immune cells called T lymphocytes interact with nerve cells in the brain and spinal cord, especially in people with multiple sclerosis, to understand how these interactions might cause nerve damage and find ways to protect nerves and improve treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | December 15, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $469,016 |
| NIH project number | 5R01NS130308-02 |
| Project ID | NIH-11001595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autoimmune diseases affecting the central nervous system, such as multiple sclerosis.
✕Less likely to help
Patients with non-autoimmune neurological disorders or those without central nervous system involvement may not benefit from this research.
What this research studies
This research investigates the mechanisms by which T lymphocytes interact with nerve cells in the central nervous system, particularly in conditions like multiple sclerosis. It focuses on the role of a specific channel, Kv3, in T cell activation and its impact on axonal injury. By utilizing various methodologies such as immunostaining, flow cytometry, and genetically modified mice, the study aims to uncover how these interactions contribute to nerve damage and explore potential neuroprotective strategies. Patients may benefit from insights that could lead to improved treatments for inflammatory demyelinating disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that protect nerve cells and improve outcomes for patients with autoimmune diseases like multiple sclerosis.
How similar studies have gone: Previous research has shown promise in understanding T cell interactions in autoimmune conditions, but this specific approach focusing on Kv3 channels is relatively novel.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Gu, Chen — Ohio State University
- Study coordinator: Gu, Chen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.