Understanding how influenza may protect against severe malaria-related lung issues in mice
Elucidating influenza-induced protection of malaria-associated respiratory distress syndrome in mice
This study is looking at how having the flu might actually help protect against serious lung problems caused by malaria, and it's aimed at finding new ways to treat people who are dealing with these tough health issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11080148 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which influenza co-infection may prevent severe lung complications associated with malaria, specifically malaria-associated respiratory distress syndrome (MA-ARDS) and malaria-associated acute lung injury (MA-ALI). The study focuses on understanding how influenza modifies the behavior of certain immune cells and blood vessel cells in the lungs, which could lead to new treatment strategies for these serious conditions. By using a mouse model, researchers aim to uncover the molecular interactions that provide this protective effect, potentially paving the way for innovative therapies for patients suffering from malaria-related lung injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of severe malaria complications, particularly those with a history of malaria infections.
Not a fit: Patients who do not have malaria or are not at risk for malaria-related respiratory distress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve outcomes for patients suffering from severe malaria-related respiratory conditions.
How similar studies have performed: While the specific approach of using influenza to protect against malaria-related lung issues is novel, similar studies have shown that co-infections can influence disease outcomes in various contexts.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Lamb, Tracey Jane — University of Utah
- Study coordinator: Lamb, Tracey Jane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.