Understanding how inflammatory signals affect cell movement in the lungs during severe respiratory infections
Official title: Identifying Inflammatory Signals Facilitating Ectopic Krt5+ Cell Migration and their Function in the Alveoli
Funded at University of Pennsylvania · NIH-10994834 · Data updated 2026-11-12
This study is looking at how certain signals in the body help specific lung cells move around during serious viral infections like COVID-19, with the goal of finding new ways to help people recover better from lung issues like ARDS.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL175909-01 |
| Project ID | NIH-10994834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced severe respiratory viral infections, particularly those who have developed ARDS.
✕Less likely to help
Patients with mild respiratory infections or those who do not have a history of severe lung injury may not benefit from this research.
What this research studies
This research investigates how inflammatory signals influence the migration of specific lung cells during severe respiratory viral infections, such as COVID-19. It focuses on a unique regeneration process in the lungs that occurs when they are injured, which involves the movement of Krt5+ cells into the alveoli. By studying the mechanisms behind this cell migration and its effects on lung function, the research aims to uncover potential therapeutic targets for improving recovery from conditions like acute respiratory distress syndrome (ARDS). Patients may benefit from insights gained about how to better manage lung health during and after severe viral infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from severe respiratory conditions, enhancing recovery and lung function.
How similar studies have gone: Previous research has shown promising results in understanding lung regeneration mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Holcomb, Nicolas Philip — University of Pennsylvania
- Study coordinator: Holcomb, Nicolas Philip
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.