Understanding how inflammatory fibroblasts develop and function in lung injuries
Induction, fate and function of inflammatory fibroblasts
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10978077
This study is looking at special cells in the lungs that can change when there's an injury, to help us understand how they might contribute to lung problems like pulmonary fibrosis, which could be helpful for patients with acute respiratory distress syndrome (ARDS).
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10978077 on ClinicalTrials.gov |
What this research studies
This research investigates the role of inflammatory fibroblasts, which are specialized cells that can emerge from normal lung fibroblasts in response to injury. By using advanced techniques like single-cell RNA sequencing and genetically modified mice, the researchers aim to trace the development and behavior of these cells in models of lung injury. The study will explore how these inflammatory fibroblasts contribute to lung conditions such as pulmonary fibrosis, which can lead to severe respiratory issues. Patients with acute respiratory distress syndrome (ARDS) may benefit from insights gained about the mechanisms of lung inflammation and fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing acute respiratory distress or those diagnosed with pulmonary fibrosis.
Not a fit: Patients with non-respiratory conditions or those who do not have inflammatory responses in their lungs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target inflammatory fibroblasts, potentially improving outcomes for patients with lung injuries and fibrosis.
How similar studies have performed: Previous research has shown promising results in understanding the role of fibroblasts in lung diseases, indicating that this approach has potential for significant findings.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEPPARD, DEAN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SHEPPARD, DEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome