Understanding how inflammation resolution affects the development of Rheumatoid Arthritis
Official title: The roles and mechanisms of inflammation resolution in the development of Rheumatoid Arthritis
Funded at University of Colorado Denver · NIH-10917241 · Data updated 2026-11-12
This study is looking at how the body naturally calms down inflammation and how that relates to the early stages of Rheumatoid Arthritis, with the goal of finding signs that could help identify people at risk so they can get help before the disease fully develops.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $592,164 |
| NIH project number | 5R01AR081812-02 |
| Project ID | NIH-10917241 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have tested positive for anti-citrullinated protein antibodies and are at risk of developing Rheumatoid Arthritis.
✕Less likely to help
Patients who are already diagnosed with advanced Rheumatoid Arthritis or those without any autoimmune markers may not benefit from this research.
What this research studies
This research investigates the mechanisms behind inflammation resolution and its role in the onset of Rheumatoid Arthritis (RA). It focuses on identifying biomarkers that indicate disease risk during the preclinical phase of RA, which is crucial for early intervention. The study will analyze lipid mediators, which are compounds involved in both the initiation and resolution of inflammation, to understand their combined effects on disease progression. By examining at-risk cohorts, the research aims to develop strategies for preventing the transition from autoimmunity to inflammatory arthritis.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for Rheumatoid Arthritis, potentially reducing the incidence of this debilitating condition.
How similar studies have gone: Previous research has shown promise in understanding the role of inflammation in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Norris, Jill M — University of Colorado Denver
- Study coordinator: Norris, Jill M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.