Understanding how inflammation resolution affects heart disease
Critical Mediators of Inflammation Resolution and Immune Memory in Atherosclerosis
This study is looking at how the body’s ability to calm down inflammation can help prevent heart disease by keeping artery plaques stable, and it hopes to find new ways to treat heart issues that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10864976 on NIH RePORTER |
What this research studies
This research investigates the role of inflammation resolution in atherosclerosis, a condition that leads to heart disease. It focuses on how specialized lipid mediators and the clearance of dying cells can influence the stability of arterial plaques. By identifying key proteins involved in these processes, the study aims to develop strategies that enhance the body's ability to resolve inflammation, potentially reducing the risk of recurrent cardiac events. Patients may benefit from insights that could lead to new treatments targeting inflammation in heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with atherosclerosis or those at high risk for cardiovascular disease.
Not a fit: Patients with non-cardiovascular conditions or those without atherosclerosis may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart health by effectively managing inflammation.
How similar studies have performed: Previous research has shown promise in targeting inflammation for cardiovascular disease, suggesting that this approach could lead to significant advancements.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Doran, Amanda C — Vanderbilt University Medical Center
- Study coordinator: Doran, Amanda C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.