Understanding how inflammation heals after a heart attack
Resolution of inflammation in healing myocardial infarcts
This research explores how the body's natural healing signals work to reduce inflammation and repair heart tissue after a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11231947 on NIH RePORTER |
What this research studies
After a heart attack, your body tries to repair the damaged heart muscle, but this process can sometimes lead to scarring and further problems. This project looks closely at specific signals within cells, called the TGF-Beta superfamily, which are crucial for how the heart heals and remodels itself. We are particularly interested in how these signals control inflammation and the formation of scar tissue. By understanding these complex cellular pathways, we hope to find new ways to help the heart heal more effectively and prevent long-term damage.
Who could benefit from this research
Good fit: This research is relevant to patients who have experienced a heart attack and are undergoing the natural healing process.
Not a fit: Patients without a history of heart attack or related heart conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that improve heart healing and reduce long-term damage after a heart attack.
How similar studies have performed: While some aspects of these cellular signaling pathways are known, this particular investigation into the Smad1 cascade's role in heart attack recovery is a novel area of focus.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Frangogiannis, Nikolaos G — Albert Einstein College of Medicine
- Study coordinator: Frangogiannis, Nikolaos G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.