Understanding how the heart heals after a heart attack
Resolution of inflammation in healing myocardial infarcts
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11002345
This research explores how the body's natural healing processes, particularly inflammation, work to repair the heart after a heart attack.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11002345 on ClinicalTrials.gov |
What this research studies
Our hearts undergo complex changes after a heart attack, including inflammation and scarring, which are crucial for recovery. This project looks closely at specific signals within heart cells, called TGF-Beta and Smad pathways, that guide these healing processes. We want to understand how these signals influence the repair, remodeling, and potential fibrosis (scarring) of the heart. By uncovering these detailed mechanisms, we hope to find new ways to support healthier heart recovery.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future clinical applications would target individuals recovering from a heart attack.
Not a fit: Patients not affected by heart attacks or related heart conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help the heart heal more effectively and reduce scarring after a heart attack.
How similar studies have performed: Previous work has shown that these signaling pathways are important in heart healing, and this project builds on those findings by exploring new aspects of their function.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANGOGIANNIS, NIKOLAOS G — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: FRANGOGIANNIS, NIKOLAOS G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.