Understanding how inflammation affects blood vessel barriers
Vascular Barrier Leakage in Inflammation
This study is looking at how inflammation makes blood vessels leak, which can let harmful substances into the body, and it's for anyone interested in understanding conditions like atherosclerosis, diabetes, and stroke, as it aims to find better treatments for these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11083629 on NIH RePORTER |
What this research studies
This research investigates how inflammation causes blood vessels to become leaky, allowing harmful substances to enter surrounding tissues. By comparing human and animal models, the team aims to identify the factors that lead to this barrier dysfunction and the specific mechanisms involved. The study focuses on understanding the structure and function of blood vessel barriers, including the signals that trigger leakage and the molecular changes that occur during inflammation. This work seeks to fill critical knowledge gaps that have hindered the development of effective therapies for conditions like atherosclerosis, diabetes, and stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from inflammatory conditions such as atherosclerosis, diabetes, or those at risk of stroke.
Not a fit: Patients with non-inflammatory vascular conditions or those not experiencing vascular barrier dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or repair vascular barrier dysfunction, improving outcomes for patients with inflammatory diseases.
How similar studies have performed: Previous research has shown promise in understanding vascular permeability, but this approach aims to address specific gaps in knowledge that have not been fully explored.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Yuan, Sarah Y — University of South Florida
- Study coordinator: Yuan, Sarah Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.