Understanding how infections trigger blood clotting
Official title: Lipid peroxidation- and pyroptosis-induced tissue factor activation in pathogen-induced blood coagulation
Funded at Beth Israel Deaconess Medical Center · NIH-10814932 · Data updated 2026-11-12
This study is looking at how infections can trigger blood clotting and aims to find new ways to prevent dangerous clots that can lead to heart attacks and strokes, especially for people who might be at risk due to these infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $164,484 |
| NIH project number | 5K99HL166778-02 |
| Project ID | NIH-10814932 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced bacterial or viral infections that may lead to complications like thrombosis.
✕Less likely to help
Patients with non-infectious causes of blood coagulation disorders may not benefit from this research.
What this research studies
This research investigates how infections, particularly bacterial and viral, can lead to the activation of tissue factor (TF), which initiates blood clotting. The study focuses on the mechanisms behind this activation, especially in the context of inflammatory cell death known as pyroptosis. By examining the role of specific proteins and reactive substances produced during infections, the research aims to uncover new therapeutic targets that could prevent dangerous blood clots associated with conditions like heart attacks and strokes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent harmful blood clots in patients with infections.
How similar studies have gone: Other research has shown promising results in understanding the mechanisms of blood coagulation in relation to infections, suggesting that this approach could yield significant insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Ansari, Shabbir Ahmed — Beth Israel Deaconess Medical Center
- Study coordinator: Ansari, Shabbir Ahmed
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.