Understanding how infections change cell membrane behavior
Detection of pathogen infection by monitoring host cell membrane dynamics
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-10892168
This study looks at how infections from harmful bacteria change the flexibility of our cells' outer layers, which might help our immune system recognize and fight off these infections, using a tiny worm called C. elegans to learn more about how this works.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10892168 on ClinicalTrials.gov |
What this research studies
This research investigates how infections by pathogenic bacteria affect the fluidity of host cell membranes, which may trigger immune responses. By studying the nematode C. elegans, researchers aim to uncover the mechanisms behind these changes and how they signal the immune system to respond to actual threats. The approach involves genetic studies to observe how these membrane dynamics influence immune signaling pathways. This could lead to a better understanding of innate immunity and how our bodies detect infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 20 years of age who may be affected by bacterial infections.
Not a fit: Patients with non-bacterial infections or those over 20 years of age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses, potentially leading to new treatments for bacterial infections.
How similar studies have performed: While the concept of surveillance immunity has been observed in plants and some animal models, this specific approach using C. elegans is relatively novel and has not been extensively tested in humans.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PUKKILA-WORLEY, READ — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: PUKKILA-WORLEY, READ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections