Understanding how infections cause sepsis and predicting patient outcomes
Official title: Integrated Host-Microbe Metagenomics for Sepsis Pathogen Surveillance, Subphenotyping and Outcome Prediction
Funded at University of California, San Francisco · NIH-11122366 · Data updated 2026-11-12
This study is looking at how different infections can lead to sepsis, a serious condition, by examining blood samples from over 1,500 patients to find out which germs are causing it and how each person's immune system reacts, with the hope of creating better ways to treat sepsis in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 21, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $662,486 |
| NIH project number | 5R01AI185511-02 |
| Project ID | NIH-11122366 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include hospitalized patients diagnosed with sepsis or septic shock.
✕Less likely to help
Patients who are not hospitalized or do not have a diagnosis of sepsis may not benefit from this research.
What this research studies
This research investigates the complex relationship between infections and sepsis, a life-threatening condition that arises from the body's response to infection. By analyzing blood samples from over 1,500 patients, the study aims to identify the specific pathogens causing sepsis and how individual immune responses vary. The research employs advanced metagenomic sequencing techniques to uncover both known and novel pathogens, and it seeks to develop new tools for predicting patient outcomes based on these findings. Ultimately, the goal is to improve treatment strategies for sepsis by better understanding its underlying mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and improved survival rates for patients suffering from sepsis.
How similar studies have gone: Previous research has shown promise in using metagenomic approaches to study infections, indicating potential for success in this novel application for sepsis.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Langelier, Charles — University of California, San Francisco
- Study coordinator: Langelier, Charles
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.