Understanding how individual differences affect cocaine addiction behaviors
Cell-Types Specific Neuroadaptations in the Nucleus Accumbens Shell Associated with Individual Differences in Cocaine-Seeking
['FUNDING_CAREER'] · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · NIH-11285160
This study is looking at why some people are more likely to become addicted to cocaine by exploring how certain brain cells react to the drug, and it aims to find ways to help prevent addiction in those at risk.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SOUTHERN ILLINOIS UNIVERSITY SCH OF MED (nih funded) |
| Locations | 1 site (SPRINGFIELD, UNITED STATES) |
| Trial ID | NIH-11285160 on ClinicalTrials.gov |
What this research studies
This research investigates why some individuals are more prone to cocaine addiction than others by examining specific brain cell adaptations in the nucleus accumbens shell. The study focuses on the relationship between the aversive effects of cocaine and the brain's response, particularly looking at certain types of neurons that may influence cocaine-seeking behavior. By utilizing advanced techniques like fiber photometry and optogenetics, the research aims to uncover the cellular mechanisms that contribute to these differences in addiction vulnerability. The ultimate goal is to identify potential therapeutic targets that could help prevent cocaine addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced cocaine use and may be at risk for developing addiction.
Not a fit: Patients who have never used cocaine or are not at risk for cocaine addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent cocaine addiction in vulnerable individuals.
How similar studies have performed: Other research has shown promising results in understanding the neurobiological factors influencing addiction, making this approach both relevant and potentially impactful.
Where this research is happening
SPRINGFIELD, UNITED STATES
- SOUTHERN ILLINOIS UNIVERSITY SCH OF MED — SPRINGFIELD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARRERO, JEFFREY PARRILLA — SOUTHERN ILLINOIS UNIVERSITY SCH OF MED
- Study coordinator: CARRERO, JEFFREY PARRILLA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder, Brain Diseases