Understanding how immune systems fight infections and stress
Official title: Defining the mechanisms that drive novel cyclic nucleotide signaling in immune defense
Funded at University of California-Irvine · NIH-11022575 · Data updated 2026-11-12
This study is looking at how different living things, especially those we don't usually think about, fight off germs and handle stress, which could help us understand our own immune system better and find new ways to treat infections and autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | February 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $379,823 |
| NIH project number | 1R35GM157311-01 |
| Project ID | NIH-11022575 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune conditions or those affected by antimicrobial-resistant infections.
✕Less likely to help
Patients with non-autoimmune related conditions or those not affected by infections may not receive direct benefits from this research.
What this research studies
This research investigates the innate immune system, which serves as the body's first line of defense against infections and plays a role in responding to cellular stress. The project aims to explore how various organisms, particularly those not commonly studied, defend themselves from pathogens, revealing insights into the evolution and function of human immunity. By examining the signaling pathways involved in immune responses, particularly those related to cyclic nucleotides, the research seeks to uncover mechanisms that could lead to new treatments for infections and autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses against infections and improving treatments for autoimmune diseases.
How similar studies have gone: Previous research has shown promise in understanding immune signaling pathways, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Morehouse, Benjamin Robert — University of California-Irvine
- Study coordinator: Morehouse, Benjamin Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.