Understanding how immune signals protect human tissues from infections
Official title: Decoding the Interferome by Mapping Genetic Interactions in Human Tissue
Funded at Columbia University Health Sciences · NIH-10904761 · Data updated 2026-11-12
This study is looking at how certain cells in your body react to infections and how a special immune signal called interferon-g helps activate them, with the goal of finding new ways to improve treatments for infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $485,725 |
| NIH project number | 5DP2AI177904-02 |
| Project ID | NIH-10904761 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of recurrent bacterial infections or those interested in understanding their immune response.
✕Less likely to help
Patients with viral infections or those not affected by bacterial infections may not receive direct benefits from this research.
What this research studies
This research investigates how non-immune cells in the body respond to infections and the role of a specific immune signal called interferon-g (IFN-g) in activating these cells. By using advanced genetic techniques, the study aims to map the interactions between various genes that contribute to the immune response in different tissues. This approach will help identify how these genes work together to protect the body from bacterial infections, potentially leading to new therapeutic strategies. Patients may benefit from insights gained about immune responses that could improve treatments for infections.
Why it matters
Potential benefit: If successful, this research could lead to new ways to enhance the immune response against bacterial infections in patients.
How similar studies have gone: Other research has shown promise in understanding immune responses through genetic mapping, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Gaudet, Ryan Gilbert — Columbia University Health Sciences
- Study coordinator: Gaudet, Ryan Gilbert
Related research
Other NIH-funded projects on the same topics.
-
Precision phenotyping of emphysema in the elderly: a study in diverse adults
Researchers will look at CT scans and lung tests in older adults to understand different forms of emphysema and how they relate to health outcomes.
-
HPV-based cervical cancer screening and treatment implementation in resource-limited settings
A collaborative project to help doctors in South Africa put HPV-based screening and same-day treatment for cervical cancer into routine care, so more people get fast, effective care.
-
Cervical cancer screening and treatment rollout in resource-poor settings
A team from Columbia and the University of Cape Town is testing how to best implement affordable, same-day HPV-based screen-and-treat for cervical cancer in public health settings.
-
Understanding SCN3A-related Developmental Epileptic Encephalopathy and Finding Better Treatments
This NIH grant focuses on how SCN3A gene variants cause developmental epileptic encephalopathy and aims to develop more effective therapies for affected patients.
-
mChoice: Boosting PrEP Use and Adherence for Black and Latino MSM with Tailored Training and Support
A national study to help Black and Latino men who have sex with men start and stick with PrEP through culturally matched provider training and patient support.
-
M-CaRE: Mobile clinics and a smart heart-lung care tool for multimorbidity
A mobile, multilingual tool plus community health workers will help screen and manage high blood pressure and COPD in diverse adult patients, especially in underserved areas.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.