Understanding how immune signals protect human tissues from infections
Decoding the Interferome by Mapping Genetic Interactions in Human Tissue
['FUNDING_OTHER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10904761
This study is looking at how certain cells in your body react to infections and how a special immune signal called interferon-g helps activate them, with the goal of finding new ways to improve treatments for infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10904761 on ClinicalTrials.gov |
What this research studies
This research investigates how non-immune cells in the body respond to infections and the role of a specific immune signal called interferon-g (IFN-g) in activating these cells. By using advanced genetic techniques, the study aims to map the interactions between various genes that contribute to the immune response in different tissues. This approach will help identify how these genes work together to protect the body from bacterial infections, potentially leading to new therapeutic strategies. Patients may benefit from insights gained about immune responses that could improve treatments for infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of recurrent bacterial infections or those interested in understanding their immune response.
Not a fit: Patients with viral infections or those not affected by bacterial infections may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to enhance the immune response against bacterial infections in patients.
How similar studies have performed: Other research has shown promise in understanding immune responses through genetic mapping, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAUDET, RYAN GILBERT — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: GAUDET, RYAN GILBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections