Understanding how immune signals affect skin inflammation and infections
Dynamic interplay between IL-36 and IL-1 in inflammation and infections
This research explores how two important immune signals, IL-36 and IL-1, work together in the skin to fight off infections and manage inflammation, especially in conditions like atopic dermatitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11093920 on NIH RePORTER |
What this research studies
Our skin's natural defenses can sometimes be weakened, making us more prone to infections, especially for those with conditions like atopic dermatitis. This project looks closely at how two specific immune messengers, called IL-36 and IL-1, interact within the skin. We want to understand their roles in both causing inflammation and protecting against common skin infections like Staphylococcus aureus and herpes viruses. By studying these interactions, we hope to uncover new ways to strengthen the skin's immunity and develop better treatments.
Who could benefit from this research
Good fit: Patients who experience recurrent skin infections or severe atopic dermatitis may eventually benefit from the insights gained from this fundamental research.
Not a fit: Patients without inflammatory skin conditions or a history of skin infections may not directly benefit from this specific research focus.
Why it matters
Potential benefit: This work could lead to new ways to prevent and treat skin infections and inflammation for people with conditions like atopic dermatitis.
How similar studies have performed: Previous work from this lab has shown the importance of IL-1 and IL-36 in immune responses, and this project builds on those findings with new, distinct mechanisms.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Jensen, Liselotte E — Temple Univ of the Commonwealth
- Study coordinator: Jensen, Liselotte E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.