Understanding how immune responses affect eye tissue in thyroid eye disease
Molecular regulation of fibroblast activation in Thyroid Eye Disease
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-10900579
This study is looking into how certain antibodies cause inflammation and changes in the eyes of people with thyroid eye disease, which can make their eyes bulge and affect their vision, and it aims to find better treatment options for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10900579 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which autoantibodies trigger inflammation and tissue remodeling in thyroid eye disease (TED), a condition that can lead to eye protrusion and vision impairment. The study focuses on the role of orbital fibroblasts and their activation through signaling pathways, particularly involving the insulin-like growth factor 1 receptor (IGF1R). By utilizing advanced techniques such as 3D cell culture, the research aims to uncover how these processes contribute to the symptoms of TED and identify potential therapeutic targets. The ultimate goal is to improve treatment options for patients suffering from this autoimmune disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with thyroid eye disease, particularly those with Graves' disease.
Not a fit: Patients without thyroid eye disease or those with other unrelated ocular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies for thyroid eye disease, improving patient outcomes and quality of life.
How similar studies have performed: Previous research has shown promising results in understanding autoimmune mechanisms in similar conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOELLER, COLLYNN FREMONT — UNIVERSITY OF ROCHESTER
- Study coordinator: WOELLER, COLLYNN FREMONT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases