Understanding how immune receptors can help fight colorectal cancer
Intracellular Innate Immune Receptors in Cancer Suppression and Immunotherapy
This study is looking at how certain immune system receptors might help us understand and treat colorectal cancer, especially for people with chronic colitis or obesity, by exploring how these conditions affect cancer growth and how we can use this knowledge to improve cancer treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10898880 on NIH RePORTER |
What this research studies
This research investigates the role of innate immune receptors in the development and treatment of colorectal cancer, particularly in patients with chronic colitis or obesity. It aims to uncover the mechanisms linking these risk factors to cancer progression and explore how innate immunity can be harnessed to improve cancer immunotherapy. By studying the interactions between genetics, microbiome, inflammation, and cancer cells, the research seeks to develop new therapeutic strategies. The ultimate goal is to translate these findings from animal models to human applications.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of chronic colitis, inflammatory bowel disease, or obesity who are at risk for colorectal cancer.
Not a fit: Patients without a history of chronic colitis, inflammatory bowel disease, or obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for colorectal cancer and potentially other gastrointestinal cancers.
How similar studies have performed: Previous research has shown promise in understanding the role of innate immunity in cancer, but this specific approach is relatively novel.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Ting, Jenny P — Univ of North Carolina Chapel Hill
- Study coordinator: Ting, Jenny P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.