Understanding how immune memory contributes to chronic autoimmune uveitis
Mechanisms of immunological memory-mediated pathogenesis in chronic autoimmune uveitis
This study is looking into how a specific type of immune cell contributes to chronic autoimmune uveitis, a condition that can cause serious vision problems, using a special mouse model to help find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Schepens Eye Research Institute NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11076655 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chronic autoimmune uveitis, a condition that can lead to severe vision loss and is often resistant to treatment. The study utilizes a newly developed mouse model that mimics the chronic form of the disease seen in humans, allowing researchers to explore the role of long-lived memory T cells in sustaining inflammation in the eye. By examining the unique characteristics of these immune cells and the local environment in the retina, the research aims to uncover new insights into the disease's progression and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic autoimmune uveitis, particularly those experiencing vision loss.
Not a fit: Patients with acute forms of uveitis or those without autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic autoimmune uveitis, potentially preserving vision for many patients.
How similar studies have performed: While there has been significant research on acute uveitis, this investigation into chronic autoimmune uveitis using a novel model is relatively untested and could provide groundbreaking insights.
Where this research is happening
Boston, United States
- Schepens Eye Research Institute — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Yihe — Schepens Eye Research Institute
- Study coordinator: Chen, Yihe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.