Understanding how immune changes in lymph nodes affect melanoma relapse
Quantitative assessment of pre-metastatic immune subversion as a risk factor for melanoma relapse
This study is looking at how solid tumors, like melanoma, can trick the immune system and spread to other parts of the body, with the goal of finding better ways to catch and treat cancer early for patients who might face a relapse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10913341 on NIH RePORTER |
What this research studies
This research investigates how solid tumors, like melanoma, can evade the immune system by altering the immune environment in nearby lymph nodes. It focuses on the mechanisms that allow tumors to create a pre-metastatic niche, which is a condition that enables cancer cells to spread. By studying the subcellular components from the primary tumor that travel through lymphatic channels, the research aims to identify ways to improve early detection and treatment strategies for patients at risk of cancer relapse.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with melanoma who are at risk of cancer recurrence.
Not a fit: Patients with melanoma who are not at risk of relapse or those with advanced metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for preventing melanoma relapse by enhancing the immune response in lymph nodes.
How similar studies have performed: Previous research has shown promise in understanding immune responses in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Markovic, Svetomir Nenad — Mayo Clinic Rochester
- Study coordinator: Markovic, Svetomir Nenad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.