Understanding how immune cells respond to pneumonia and lung injury
Official title: Migration and resolution, lung microenvironment and mechanisms: examining the diverse responses of neutrophils during S. pneumoniae pneumonia and acute lung injury
Funded at Univ of North Carolina Chapel Hill · NIH-11133797 · Data updated 2026-11-12
This study is looking at how a type of white blood cell called neutrophils responds when the lungs are infected with a germ that causes pneumonia, to see if they help heal the lungs or make things worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | May 15, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $759,983 |
| NIH project number | 1R01HL175463-01A1 |
| Project ID | NIH-11133797 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults suffering from pneumonia or acute lung injury, particularly those caused by bacterial infections.
✕Less likely to help
Patients with chronic lung diseases or those not experiencing acute respiratory issues may not benefit from this research.
What this research studies
This research investigates the immune response of neutrophils, a type of white blood cell, during infections caused by S. pneumoniae, which is a leading cause of pneumonia and acute lung injury. The study aims to understand how these immune cells change their behavior and function in the lungs, particularly in response to infection and injury. By examining the unique environments within the lungs, the researchers hope to uncover how neutrophils can either help repair lung tissue or contribute to further damage. This research involves detailed analysis of neutrophil characteristics and their interactions in the lung microenvironment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for pneumonia and acute lung injuries, enhancing recovery and outcomes for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in lung infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Doerschuk, Claire M — Univ of North Carolina Chapel Hill
- Study coordinator: Doerschuk, Claire M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.