Understanding how immune cells respond to different signals
Official title: Characterizing functional states of macrophages via their stimulus-responses
Funded at University of California Los Angeles · NIH-11092249 · Data updated 2026-11-12
This study is looking at how important immune cells called macrophages behave when they receive different signals, which could help us understand their role in conditions like autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $695,335 |
| NIH project number | 5R01AI173214-03 |
| Project ID | NIH-11092249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune conditions or those experiencing immune-related issues.
✕Less likely to help
Patients with non-autoimmune conditions or those not experiencing immune system-related symptoms may not benefit from this research.
What this research studies
This research investigates the behavior of macrophages, which are crucial immune cells that respond to various stimuli in the body. By examining how these cells react to different signals, the study aims to uncover the mechanisms that dictate their responses and how these responses vary depending on the tissue environment. The approach involves advanced single-cell measurements and computational analyses to quantify the specificity and context of macrophage functions. This could lead to a better understanding of immune responses in various conditions, including autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses, potentially leading to improved treatments for autoimmune diseases and other conditions.
How similar studies have gone: Previous research has shown promise in understanding immune cell behavior, but this approach focusing on single-cell responses is relatively novel.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Hoffmann, Alexander — University of California Los Angeles
- Study coordinator: Hoffmann, Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.