Understanding how immune cells respond after brain injuries from blasts
Breaching CNS barriers: Deciphering the spatiotemporal regulation of immune cell surveillance following blast TBI
['FUNDING_OTHER'] · WHITE RIVER JUNCTION VA MEDICAL CENTER · NIH-10923422
This study is looking at how the immune system reacts in the brain after blast injuries, especially in military personnel, to better understand how this might lead to long-term issues like anxiety and depression, with the hope of finding better treatments to help people recover.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WHITE RIVER JUNCTION VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (White River Junction, UNITED STATES) |
| Trial ID | NIH-10923422 on ClinicalTrials.gov |
What this research studies
This research investigates the immune response in the central nervous system (CNS) following blast traumatic brain injury (bTBI), particularly in military personnel. The study aims to uncover the mechanisms that regulate inflammation and immune cell infiltration into the CNS after such injuries. By utilizing advanced imaging techniques, researchers hope to identify how these immune responses contribute to chronic neuropsychiatric issues like anxiety and depression. The ultimate goal is to inform personalized treatment strategies that could improve recovery outcomes for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are military personnel who have experienced blast traumatic brain injuries and are suffering from related neuropsychiatric symptoms.
Not a fit: Patients with brain injuries not related to blast exposure or those without neuropsychiatric complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new immunomodulation therapies that enhance recovery and quality of life for patients with blast-related brain injuries.
How similar studies have performed: Previous research has shown promise in understanding immune responses in brain injuries, but this specific approach to blast TBI is relatively novel.
Where this research is happening
White River Junction, UNITED STATES
- WHITE RIVER JUNCTION VA MEDICAL CENTER — White River Junction, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DISANO, KRISTA — WHITE RIVER JUNCTION VA MEDICAL CENTER
- Study coordinator: DISANO, KRISTA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Affective Disorders, Anxiety Disorders