Understanding how immune cells regulate their function and adaptability
Cis-Regulatory Circuits for ILC Function and Plasticity
This study is looking at how certain immune cells called innate lymphoid cells work to fight off infections without causing harm to the body, and it’s especially for people interested in understanding autoimmune diseases like inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11050258 on NIH RePORTER |
What this research studies
This research investigates the regulatory mechanisms that control the function of innate lymphoid cells (ILCs) in the immune system, particularly how these cells respond to pathogens while minimizing tissue damage. By analyzing chromatin landscapes and regulatory elements in ILCs, the study aims to uncover how these immune cells contribute to autoimmune diseases like inflammatory bowel disease. The approach involves profiling immune cells derived from human tissues to identify genetic factors that influence their behavior and response to inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases, particularly those with inflammatory bowel disease.
Not a fit: Patients without autoimmune conditions or those who do not have a history of inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoimmune diseases by targeting the regulatory pathways of immune cells.
How similar studies have performed: Previous research has shown success in understanding immune cell regulation, suggesting that this approach may yield valuable insights into autoimmune disease mechanisms.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Colonna, Marco — Washington University
- Study coordinator: Colonna, Marco
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.