Understanding how immune cells interact in lung injury and scarring
Official title: Immune crosstalk in lung injury and fibrosis
Funded at University of Michigan at Ann Arbor · NIH-11030427 · Data updated 2026-11-12
This study is looking at how lung cells and immune cells work together when the lungs are injured and develop scarring, to help us understand why people with lung fibrosis struggle to fight off infections, and it may involve patients to learn more about their immune responses and how to make them better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2031 |
| Funding year | 2025 |
| Award (this year) | $1,061,189 |
| NIH project number | 1R35HL176572-01 |
| Project ID | NIH-11030427 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with lung fibrosis or those who have experienced lung injury, particularly after hematopoietic stem cell transplantation.
✕Less likely to help
Patients without lung injury or fibrosis, or those with other unrelated respiratory conditions, may not benefit from this research.
What this research studies
This research investigates the complex interactions between immune cells and lung cells during injury and the development of fibrosis, a condition characterized by scarring in the lungs. The study focuses on how specific growth factors produced by lung cells influence the behavior of immune cells, particularly in the context of bacterial infections. By exploring these mechanisms, the research aims to identify why patients with lung fibrosis have difficulty fighting off certain infections. Patients may be involved in understanding their immune responses and how these responses can be improved.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response in patients with lung fibrosis, improving their ability to fight infections.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in lung conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Moore, Bethany B. — University of Michigan at Ann Arbor
- Study coordinator: Moore, Bethany B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.