Understanding how immune cells control inflammation in lung injury
A redox-sensitive switch in the macrophage nucleus regulates acute phaseinflammatory injury
This research explores how certain signals inside immune cells called macrophages control severe inflammation, especially in conditions like Acute Respiratory Distress Syndrome (ARDS).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11354298 on NIH RePORTER |
What this research studies
Our bodies have immune cells called macrophages that help fight infections and heal injuries. This project looks at how special signals, like reactive oxygen and nitrogen, inside these macrophages act like a switch to turn inflammation on or off. We believe that when this switch stays "on" for too long due to oxidative stress, it can lead to severe lung damage, as seen in ARDS. By understanding this process, we hope to find new ways to help the body resolve inflammation and heal.
Who could benefit from this research
Good fit: Patients with or at high risk for Acute Respiratory Distress Syndrome (ARDS), especially those with underlying oxidative stress from conditions like old age, smoking, or autoimmune diseases, are the focus of this research.
Not a fit: Patients whose inflammatory lung injury is not related to the specific redox-sensitive pathways in macrophages being studied may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help control inflammation in the lungs, potentially reducing the severity of Acute Respiratory Distress Syndrome (ARDS) and improving patient recovery.
How similar studies have performed: This research builds upon new discoveries about how reactive oxygen and nitrogen species regulate immune responses, exploring a novel mechanism for controlling inflammation.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Bonini, Marcelo G. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Bonini, Marcelo G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.