Understanding how immune cells contribute to rheumatoid arthritis
Identifying a novel pathway that regulates RA immunometabolism
This research explores a new way that certain immune cells contribute to rheumatoid arthritis, hoping to find better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10886071 on NIH RePORTER |
What this research studies
Rheumatoid arthritis causes painful joint inflammation, partly due to specific immune cells called macrophages. In patients who don't respond well to current treatments, these cells become more inflammatory and change how they use energy. We are looking for a new biological pathway that causes these cells to become harmful. By understanding this process, we aim to discover new ways to stop the inflammation and joint damage in rheumatoid arthritis.
Who could benefit from this research
Good fit: Patients living with rheumatoid arthritis, especially those who do not respond well to current therapies, could potentially benefit from future treatments developed from this research.
Not a fit: Patients without rheumatoid arthritis or other autoimmune conditions would not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new medications that target the specific cellular processes causing inflammation in rheumatoid arthritis.
How similar studies have performed: This research proposes a novel pathway involving a specific cytokine and SDC1, representing a new and untested approach to understanding rheumatoid arthritis.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Shahrara, Shiva — University of Illinois at Chicago
- Study coordinator: Shahrara, Shiva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.