Understanding how immune cells communicate and move in the body
The Molecular Basis for Integrin-Mediated Bidirectional Signaling
This study is looking at how certain proteins on immune cells help them stick together and move around, which could lead to new ways to understand and treat diseases like autoimmune disorders, cancer, and infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10873841 on NIH RePORTER |
What this research studies
This research investigates the role of β2 integrins, which are proteins on the surface of immune cells called leukocytes, in their ability to adhere, migrate, and communicate with each other. By using advanced imaging techniques, the study aims to uncover the molecular mechanisms that activate these integrins and how they interact with other molecules. This knowledge could lead to better understanding and treatment of various diseases, including autoimmune disorders, cancers, and infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases, certain cancers, or other conditions related to immune cell signaling and function.
Not a fit: Patients with conditions unrelated to immune cell function or those who do not have autoimmune diseases or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases, cancers, and other conditions linked to immune cell dysfunction.
How similar studies have performed: Previous research has shown that understanding integrin signaling can lead to significant advancements in treating related diseases, indicating a promising avenue for this investigation.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Campbell, Melody G — Fred Hutchinson Cancer Center
- Study coordinator: Campbell, Melody G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.