Understanding how immune cells cause lung cell death in acute lung injury
GasderminD regulation of Acute Lung Injury
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10868705
This study is looking at how certain immune cells can cause lung cells to die during a serious condition called acute respiratory distress syndrome (ARDS), and it hopes to find new ways to help treat ARDS by understanding the role of a specific protein involved in this process.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10868705 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which immune cells, specifically monocytes, contribute to the death of lung endothelial cells during acute respiratory distress syndrome (ARDS). The study aims to explore the role of a protein called GasderminD in this process, using both animal models and samples from ARDS patients. By identifying how these immune cells induce cell death, the research seeks to uncover potential new therapeutic strategies for treating ARDS, a condition with currently limited treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute respiratory distress syndrome or acute lung injury.
Not a fit: Patients with chronic lung conditions or those not experiencing acute respiratory distress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for acute lung injury and ARDS, improving patient outcomes.
How similar studies have performed: While the specific approach of targeting GasderminD in ARDS is novel, similar research has shown promise in understanding immune cell functions in other conditions.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SARKAR, ANASUYA — OHIO STATE UNIVERSITY
- Study coordinator: SARKAR, ANASUYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome