Understanding how immune cells cause inflammation in autoimmune diseases
Molecular regulation of TLR2-mediated autoimmune inflammation
['FUNDING_R01'] · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · NIH-10507768
This study is looking at how specific immune cells called CD4+ T cells get activated and cause problems in autoimmune diseases like multiple sclerosis, with the hope of finding new ways to help people manage these conditions better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROSALIND FRANKLIN UNIV OF MEDICINE & SCI (nih funded) |
| Locations | 1 site (NORTH CHICAGO, UNITED STATES) |
| Trial ID | NIH-10507768 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which certain immune cells, specifically CD4+ T cells, become activated and contribute to autoimmune diseases like multiple sclerosis. The study focuses on how these cells respond to self-antigens and the resulting inflammation in the central nervous system. By exploring the genetic and epigenetic factors that enhance the pathogenicity of these immune cells, the research aims to uncover potential therapeutic targets for controlling autoimmune responses. Patients may benefit from insights that could lead to new treatments for autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autoimmune diseases, particularly those with multiple sclerosis.
Not a fit: Patients with non-autoimmune conditions or those not diagnosed with autoimmune diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better control autoimmune inflammation and improve outcomes for patients with autoimmune diseases.
How similar studies have performed: Previous research has shown success in understanding immune cell mechanisms in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
NORTH CHICAGO, UNITED STATES
- ROSALIND FRANKLIN UNIV OF MEDICINE & SCI — NORTH CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REYNOLDS, JOSEPH MICHAEL — ROSALIND FRANKLIN UNIV OF MEDICINE & SCI
- Study coordinator: REYNOLDS, JOSEPH MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease