Understanding how immune cells behave in lung injuries
Official title: Spatio-temporal regulation of pulmonary neutrophil plasticity
Funded at University of Illinois at Chicago · NIH-11099883 · Data updated 2026-11-12
This study is looking at how a type of immune cell called neutrophils reacts and changes when the lungs are hurt by infections or other things in the environment, with the goal of finding new ways to help improve lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $400,825 |
| NIH project number | 5R01AI182185-02 |
| Project ID | NIH-11099883 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults experiencing acute lung injuries or conditions such as Acute Respiratory Distress Syndrome (ARDS).
✕Less likely to help
Patients with chronic lung conditions or those not currently experiencing acute lung injuries may not benefit from this research.
What this research studies
This research investigates how neutrophils, a type of immune cell, adapt and respond during acute lung injuries caused by infections or environmental factors. Using advanced imaging techniques, the study aims to observe the behavior and changes in these cells in real-time within the lungs. By analyzing how these cells move and function in response to injury, the research seeks to uncover new insights into the body's defense mechanisms and potential therapeutic targets for improving lung health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to respond to lung injuries and improve recovery outcomes for patients.
How similar studies have gone: Previous research has shown promising results in understanding immune cell behavior in other types of injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Tsukasaki, Yoshikazu — University of Illinois at Chicago
- Study coordinator: Tsukasaki, Yoshikazu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.