Understanding how immune cells become exhausted in Type 1 Diabetes
Defining mechanisms of CD8 T cell exhaustion in T1D
This study is looking at how certain immune cells get tired out in people with Type 1 Diabetes and how a specific signaling pathway might affect this, with the hope of finding better ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10796940 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind CD8 T cell exhaustion in individuals with Type 1 Diabetes (T1D), an autoimmune condition where the immune system attacks insulin-producing cells. The study focuses on the role of the IL-2/IL-15 signaling pathway in T1D, examining how variations in this pathway affect the behavior of immune cells. By analyzing blood samples from T1D patients, researchers aim to identify factors that contribute to immune cell exhaustion and how this impacts disease progression and response to treatments. The goal is to uncover insights that could lead to improved therapies for managing T1D.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals recently diagnosed with Type 1 Diabetes who are experiencing varying rates of disease progression.
Not a fit: Patients with Type 1 Diabetes who are not recently diagnosed or those with advanced disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune function and slowing the progression of Type 1 Diabetes.
How similar studies have performed: Previous research has shown promising results in understanding immune cell behavior in chronic conditions, suggesting that this approach may yield valuable insights for T1D.
Where this research is happening
Seattle, United States
- Benaroya Research Inst at Virginia Mason — Seattle, United States (Active)
Researchers
- Principal investigator: Long, S Alice — Benaroya Research Inst at Virginia Mason
- Study coordinator: Long, S Alice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.