Understanding how immune cells attack insulin-producing cells in type 1 diabetes
Single Cell Genomics to Resolve Control of Immune Cell Function During Type 1 Diabetes
This study is looking at how certain immune cells, called autoreactive T cells, contribute to type 1 diabetes by attacking the insulin-producing cells in the pancreas, with the hope of finding new treatments to help prevent or reduce this harmful response.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10875446 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, particularly autoreactive T cells, in the development of type 1 diabetes (T1D). By examining how these T cells interact with pancreatic islet cells, the study aims to uncover the mechanisms that lead to the destruction of insulin-producing beta cells. Using advanced single-cell genomics techniques, researchers will analyze the cellular environment of individual islets to identify factors that influence T cell behavior. The goal is to develop targeted therapies that can prevent or mitigate the autoimmune response in T1D.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes or those at high risk of developing the condition.
Not a fit: Patients with type 2 diabetes or other non-autoimmune related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect insulin-producing cells and improve outcomes for individuals with type 1 diabetes.
How similar studies have performed: Previous research has shown promise in understanding immune responses in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Scott-Browne, James — National Jewish Health
- Study coordinator: Scott-Browne, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.