Understanding how immune cells are programmed in autoimmune diseases
Connecting epigenetic programming of T cells with molecular traits of the immune system in health and disease
This work explores how immune cells, specifically T cells, are programmed at a genetic level in people with autoimmune conditions like multiple sclerosis, rheumatoid arthritis, and type 1 diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11141661 on NIH RePORTER |
What this research studies
We know that genetic differences often contribute to chronic diseases, especially in the immune system. This project looks closely at how these genetic differences affect T cells, which are key players in keeping our immune system balanced. We are particularly interested in how the 'epigenetic programming' of T cells, which involves changes to DNA that turn genes on or off, is linked to these genetic differences and contributes to autoimmune diseases. By understanding these connections, we hope to uncover new ways to understand why these diseases develop.
Who could benefit from this research
Good fit: This foundational research is relevant to patients with autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and type 1 diabetes, as it seeks to understand the underlying biology of their conditions.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the root causes of autoimmune diseases, potentially paving the way for new diagnostic tools or targeted treatments.
How similar studies have performed: While the specific link between epigenetic changes and disease-associated variants is still being clarified, previous studies have shown the importance of non-coding genetic regions and T cell epigenetics in autoimmune diseases.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Issuree, Priya — University of Iowa
- Study coordinator: Issuree, Priya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.