Understanding how immune cells affect lung injury and recovery
Macrophage Plasticity in Inflammatory Lung Injury
This study is looking at how certain immune cells called macrophages behave during lung injuries and breathing problems, with the goal of finding new treatments that can help your lungs heal while still keeping your body strong against infections.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10895330 on NIH RePORTER |
What this research studies
This research investigates the role of macrophages, a type of immune cell, in the inflammatory processes associated with Acute Lung Injury and Acute Respiratory Distress Syndrome (ALI/ARDS). By exploring how these cells can change their behavior in response to different signals, the research aims to identify targeted treatments that can reduce lung damage while preserving the body's ability to fight infections. The approach involves detailed analysis of macrophage functions, including their ability to promote inflammation and facilitate healing in the lungs. Patients may benefit from new therapies that specifically modulate these immune responses to improve recovery outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with Acute Lung Injury or Acute Respiratory Distress Syndrome.
Not a fit: Patients with chronic lung diseases or those not experiencing acute lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from severe lung injuries, improving recovery rates and overall health outcomes.
How similar studies have performed: Previous research has shown promise in targeting immune cell functions to improve outcomes in lung injury, suggesting that this approach could be effective.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Mehta, Dolly — University of Illinois at Chicago
- Study coordinator: Mehta, Dolly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.