Understanding how immune cells affect kidney damage during urinary tract infections
Contrasting roles for neutrophils and macrophages during acute pyelonephritis
This study is looking at how certain immune cells in your body affect kidney damage after urinary tract infections, with the goal of finding new ways to help prevent long-term kidney problems for people who experience these infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11081780 on NIH RePORTER |
What this research studies
This research investigates the roles of two types of immune cells, neutrophils and macrophages, in the development of kidney damage following urinary tract infections (UTIs), specifically acute pyelonephritis. The study aims to understand how these cells contribute to inflammation and kidney fibrosis, which can lead to long-term kidney problems. By examining the immune response during these infections, the research seeks to identify potential new treatments that could prevent kidney injury and improve patient outcomes. Patients with UTIs may benefit from insights gained about their immune response and potential therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acute pyelonephritis or recurrent urinary tract infections.
Not a fit: Patients with chronic kidney disease unrelated to urinary tract infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent kidney damage in patients suffering from urinary tract infections.
How similar studies have performed: Previous research has shown that targeting immune responses can lead to improved outcomes in similar conditions, suggesting a promising avenue for this investigation.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Ruiz Rosado, Juan de Dios — Research Inst Nationwide Children's Hosp
- Study coordinator: Ruiz Rosado, Juan de Dios
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.