Understanding how immune cells affect heart and kidney health in type 1 diabetes
Official title: Immunometabolism and the Cardio-Renal Axis in T1D-associated Atherosclerosis: Insights from the CaRe T1D Biobank
Funded at University of Washington · NIH-11072169 · Data updated 2026-11-12
This study is looking at how certain immune cells might affect heart and kidney problems in people with type 1 diabetes by examining blood samples, so we can better understand the link between these cells and cardiovascular disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 18, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,080,680 |
| NIH project number | 1U01DK142249-01 |
| Project ID | NIH-11072169 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are at risk for cardiovascular disease.
✕Less likely to help
Patients without type 1 diabetes or those who do not have cardiovascular disease may not benefit from this research.
What this research studies
This research investigates the connection between immune cell behavior and cardiovascular disease in individuals with type 1 diabetes (T1D). By analyzing blood samples from the CaRe T1D biobank, researchers will use advanced sequencing techniques to identify specific T cell populations that may contribute to atherosclerosis, a condition that leads to heart disease. The study aims to understand how these T cells interact with blood vessel cells and how their presence correlates with the severity of heart and kidney issues in T1D patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular disease in patients with type 1 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding immune cell roles in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Bornfeldt, Karin E. — University of Washington
- Study coordinator: Bornfeldt, Karin E.
Related research
Other NIH-funded projects on the same topics.
-
Coronary disease and immune activation in people with HIV and tuberculosis coinfection
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
-
PFAS may speed up artery disease by changing bile acids
Aims to see if PFAS chemicals make cholesterol rise and arteries more likely to harden, using a human-similar mouse model to understand how this could affect people.
-
IgE antibodies to alpha-gal and heart disease in mice and people
A study to understand how specific IgE antibodies against alpha-gal might influence the development and severity of atherosclerosis in humans and mouse models.
-
Fibroblast Growth Factor 1 to Reduce High Lipids and Plaque in Adults with Diabetes
A new approach uses a modified FGF1 protein to lower bad cholesterol and prevent artery plaque buildup in adults with Type 2 diabetes, aiming for safer and more effective treatment.
-
Atherosclerosis in cocaine addiction: imaging risk with PET/MR
This project uses PET/MR imaging to look for early artery disease in people with cocaine use disorder to help prevent strokes or other brain injuries.
-
How low blood flow after brain artery narrowing affects the vessel lining
This work looks at whether areas of low blood flow downstream of narrowed brain arteries cause vessel lining damage and raise the chance of another stroke, for people with intracranial artery narrowing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.