Understanding how immune cells affect heart and kidney health in type 1 diabetes
Immunometabolism and the Cardio-Renal Axis in T1D-associated Atherosclerosis: Insights from the CaRe T1D Biobank
This study is looking at how certain immune cells might affect heart and kidney problems in people with type 1 diabetes by examining blood samples, so we can better understand the link between these cells and cardiovascular disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11072169 on NIH RePORTER |
What this research studies
This research investigates the connection between immune cell behavior and cardiovascular disease in individuals with type 1 diabetes (T1D). By analyzing blood samples from the CaRe T1D biobank, researchers will use advanced sequencing techniques to identify specific T cell populations that may contribute to atherosclerosis, a condition that leads to heart disease. The study aims to understand how these T cells interact with blood vessel cells and how their presence correlates with the severity of heart and kidney issues in T1D patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are at risk for cardiovascular disease.
Not a fit: Patients without type 1 diabetes or those who do not have cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular disease in patients with type 1 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding immune cell roles in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Bornfeldt, Karin E. — University of Washington
- Study coordinator: Bornfeldt, Karin E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.