Understanding how immune cells affect blood flow and oxygen in stroke patients
Official title: Defining the Spatiotemporal Underpinnings of Neutrophil Recruitment, Microvascular Flow, and Oxygenation in Ischemic Stroke
Funded at State University New York Stony Brook · NIH-10999436 · Data updated 2026-11-12
This study is looking at how certain immune cells called neutrophils behave after a stroke when blood flow returns to the brain, using mice to help us understand how these cells might cause problems like tissue damage, with the hope of finding better treatments for people who have had a stroke.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $276,085 |
| NIH project number | 5K08NS121597-03 |
| Project ID | NIH-10999436 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke, particularly those with large vessel occlusion.
✕Less likely to help
Patients who have not experienced a stroke or those with hemorrhagic stroke may not benefit from this research.
What this research studies
This research investigates the role of immune cells, specifically neutrophils, in the aftermath of ischemic stroke, where blood flow is restored to the brain. By using a mouse model that mimics human stroke conditions, the study aims to identify how these immune cells contribute to complications like microvascular obstruction and tissue damage. Advanced imaging and histopathological techniques will be employed to track the behavior of neutrophils over time, providing insights that could lead to improved treatments for stroke patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce disability and improve recovery outcomes for stroke patients.
How similar studies have gone: While preclinical studies have shown promise in blocking neutrophil recruitment, similar approaches have not yet succeeded in human trials, making this research both challenging and potentially groundbreaking.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Nadkarni, Neil Avadhoot — State University New York Stony Brook
- Study coordinator: Nadkarni, Neil Avadhoot
Related research
Other NIH-funded projects on the same topics.
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Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
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EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
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Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
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How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
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Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.