Understanding how immune cells affect blood flow and oxygen in stroke patients
Defining the Spatiotemporal Underpinnings of Neutrophil Recruitment, Microvascular Flow, and Oxygenation in Ischemic Stroke
This study is looking at how certain immune cells called neutrophils behave after a stroke when blood flow returns to the brain, using mice to help us understand how these cells might cause problems like tissue damage, with the hope of finding better treatments for people who have had a stroke.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10999436 on NIH RePORTER |
What this research studies
This research investigates the role of immune cells, specifically neutrophils, in the aftermath of ischemic stroke, where blood flow is restored to the brain. By using a mouse model that mimics human stroke conditions, the study aims to identify how these immune cells contribute to complications like microvascular obstruction and tissue damage. Advanced imaging and histopathological techniques will be employed to track the behavior of neutrophils over time, providing insights that could lead to improved treatments for stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke, particularly those with large vessel occlusion.
Not a fit: Patients who have not experienced a stroke or those with hemorrhagic stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce disability and improve recovery outcomes for stroke patients.
How similar studies have performed: While preclinical studies have shown promise in blocking neutrophil recruitment, similar approaches have not yet succeeded in human trials, making this research both challenging and potentially groundbreaking.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Nadkarni, Neil Avadhoot — State University New York Stony Brook
- Study coordinator: Nadkarni, Neil Avadhoot
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.