Understanding how IL-9 interacts with immune cells to influence autoimmune diseases
Defining a type II IL-9R
This study is looking at how a special receptor for a protein called IL-9 affects the immune system and inflammation, especially in cells that line the airways, to find new ways to help treat autoimmune and allergic diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10847462 on NIH RePORTER |
What this research studies
This research investigates the role of a specific receptor for the cytokine IL-9, which is involved in immune responses and inflammation. By exploring how IL-9 signals through this receptor in both immune and non-immune cells, particularly airway epithelial cells, the study aims to uncover new mechanisms that could be targeted for treatment. The researchers will use genetically modified mice and laboratory models to analyze the effects of IL-9 signaling. This approach could lead to new insights into treating autoimmune and allergic diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases or allergic conditions.
Not a fit: Patients with non-autoimmune or non-allergic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients suffering from autoimmune and allergic conditions.
How similar studies have performed: Previous research has shown promising results in targeting cytokine-receptor interactions for treating autoimmune diseases, suggesting potential success for this approach.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Kaplan, Mark H — Indiana University Indianapolis
- Study coordinator: Kaplan, Mark H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.