Understanding how IL-36 cytokines affect skin infections
IL-36 activity during skin infections
['FUNDING_R21'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-10809204
This study is looking at how certain proteins called IL-36 affect skin infections and conditions like eczema, with the goal of finding better treatments for people dealing with these issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10809204 on ClinicalTrials.gov |
What this research studies
This research investigates the role of IL-36 cytokines in skin infections and inflammatory conditions. It aims to uncover how these cytokines are activated and inactivated, which is crucial for developing new treatments. By studying models of conditions like atopic dermatitis and infections caused by herpes simplex virus and Staphylococcus aureus, the research seeks to improve our understanding of immune responses in the skin. The findings could inform clinical trials for therapies targeting IL-36, potentially leading to more effective treatments for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from atopic dermatitis, psoriasis, or skin infections.
Not a fit: Patients with non-inflammatory skin conditions or those not affected by IL-36 related pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage skin infections and inflammatory skin conditions.
How similar studies have performed: Previous research has shown promising results in understanding cytokine roles in inflammation, suggesting potential for success in this area as well.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JENSEN, LISELOTTE E — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: JENSEN, LISELOTTE E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Chronic Disease, chronic disorder