Understanding how IL-36 cytokines affect skin infections
Official title: IL-36 activity during skin infections
Funded at Temple Univ of the Commonwealth · NIH-10809204 · Data updated 2026-11-12
This study is looking at how certain proteins called IL-36 affect skin infections and conditions like eczema, with the goal of finding better treatments for people dealing with these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $383,570 |
| NIH project number | 1R21AR082631-01A1 |
| Project ID | NIH-10809204 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from atopic dermatitis, psoriasis, or skin infections.
✕Less likely to help
Patients with non-inflammatory skin conditions or those not affected by IL-36 related pathways may not benefit from this research.
What this research studies
This research investigates the role of IL-36 cytokines in skin infections and inflammatory conditions. It aims to uncover how these cytokines are activated and inactivated, which is crucial for developing new treatments. By studying models of conditions like atopic dermatitis and infections caused by herpes simplex virus and Staphylococcus aureus, the research seeks to improve our understanding of immune responses in the skin. The findings could inform clinical trials for therapies targeting IL-36, potentially leading to more effective treatments for patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage skin infections and inflammatory skin conditions.
How similar studies have gone: Previous research has shown promising results in understanding cytokine roles in inflammation, suggesting potential for success in this area as well.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Jensen, Liselotte E — Temple Univ of the Commonwealth
- Study coordinator: Jensen, Liselotte E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.