Understanding how IL-2 helps regulate immune tolerance
Official title: Mechanisms of Il-2-mediated immune tolerance
Funded at Benaroya Research Inst at Virginia Mason · NIH-10909803 · Data updated 2026-11-12
This study is looking at how a special treatment can help boost a type of immune cell that keeps your body from attacking itself, which could lead to new ways to manage autoimmune diseases and improve your immune health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 18, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $216,625 |
| NIH project number | 5R21AI172140-02 |
| Project ID | NIH-10909803 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune diseases who may benefit from improved immune regulation.
✕Less likely to help
Patients with non-autoimmune conditions or those who do not have a significant immune tolerance issue may not receive benefits from this research.
What this research studies
This research investigates the role of IL-2 in the development and function of regulatory T cells, which are crucial for maintaining immune tolerance. By using a specially designed IL-2 mutein that selectively targets these regulatory T cells, the study aims to enhance their abundance and function in the body. The approach involves examining how this treatment can suppress autoimmune responses and promote long-lasting protection against autoimmune diseases. Patients may benefit from insights into new therapeutic strategies that could improve their immune regulation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage autoimmune diseases by enhancing the body's natural immune tolerance.
How similar studies have gone: Previous research has shown promising results with similar approaches targeting regulatory T cells, indicating potential for success in this novel application.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Campbell, Daniel J — Benaroya Research Inst at Virginia Mason
- Study coordinator: Campbell, Daniel J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.